A multicomponent reaction between H2, CO, an unsaturated carboxylic acid derivative, and binucleophiles has been discovered. This process represents a combination of diversity-oriented synthesis and multicomponent reactions including amidation and hydroformylation, followed by nucleophilic addition to an N-acyliminium ion allowing the generation of six new bonds. Using π-nucleophiles, the sequence turns into a multicomponent Pictet-Spengler reaction.
Airiau, E., Girard, N., Mann, A., Salvadori, J., Taddei, M. (2009). Four-Component Reactions toward Fused Heterocyclic Rings. ORGANIC LETTERS, 11(22), 5314-5317 [10.1021/ol902279m].
Four-Component Reactions toward Fused Heterocyclic Rings
Taddei, Maurizio
2009-01-01
Abstract
A multicomponent reaction between H2, CO, an unsaturated carboxylic acid derivative, and binucleophiles has been discovered. This process represents a combination of diversity-oriented synthesis and multicomponent reactions including amidation and hydroformylation, followed by nucleophilic addition to an N-acyliminium ion allowing the generation of six new bonds. Using π-nucleophiles, the sequence turns into a multicomponent Pictet-Spengler reaction.
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https://hdl.handle.net/11365/9068
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