A multicomponent reaction between H2, CO, an unsaturated carboxylic acid derivative, and binucleophiles has been discovered. This process represents a combination of diversity-oriented synthesis and multicomponent reactions including amidation and hydroformylation, followed by nucleophilic addition to an N-acyliminium ion allowing the generation of six new bonds. Using π-nucleophiles, the sequence turns into a multicomponent Pictet-Spengler reaction.

Airiau, E., Girard, N., Mann, A., Salvadori, J., & Taddei, M. (2009). Four-Component Reactions toward Fused Heterocyclic Rings. ORGANIC LETTERS, 11, 5314-5317.

Four-Component Reactions toward Fused Heterocyclic Rings

TADDEI, MAURIZIO
2009

Abstract

A multicomponent reaction between H2, CO, an unsaturated carboxylic acid derivative, and binucleophiles has been discovered. This process represents a combination of diversity-oriented synthesis and multicomponent reactions including amidation and hydroformylation, followed by nucleophilic addition to an N-acyliminium ion allowing the generation of six new bonds. Using π-nucleophiles, the sequence turns into a multicomponent Pictet-Spengler reaction.
Airiau, E., Girard, N., Mann, A., Salvadori, J., & Taddei, M. (2009). Four-Component Reactions toward Fused Heterocyclic Rings. ORGANIC LETTERS, 11, 5314-5317.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/9068
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