We report a patient who developed a chronic sensory-motor polyneuropathy and a progressive myelopathy 4 years after a tick bite. An increased serum antibody titer to Borrelia burgdorferi suggested a diagnosis of Lyme neuroborreliosis, although a concomitant cervical spondylosis probably contributed to spinal cord damage. Treatment with ceftriaxone resulted in a marked improvement of neuropathic symptoms, providing indirect evidence of spirochetal infection. Search for B. burgdorferi DNA by polymerase chain reaction amplification on sural nerve confirmed the diagnosis, demonstrating that the spirochete localized in the peripheral nervous system. The presence of complement membrane attack complex deposits and macrophage infiltrates around epineurial vessels and within the endoneurium suggests that the neuropathy in our patient was immune-mediated.

Maimone, D., Villanova, M., Stanta, G., Bonin, S., Malandrini, A., Guazzi, G.C., et al. (1997). Detection of Borrelia burgdoferi DNA and complement attack complex deposits in the sural nerve of a patient with chronic polyneuropathy and tertiary Lyme disease. MUSCLE & NERVE, 20, 969-975 [10.1002/(SICI)1097-4598].

Detection of Borrelia burgdoferi DNA and complement attack complex deposits in the sural nerve of a patient with chronic polyneuropathy and tertiary Lyme disease

MALANDRINI, ALESSANDRO;ANNUNZIATA, PASQUALE
1997

Abstract

We report a patient who developed a chronic sensory-motor polyneuropathy and a progressive myelopathy 4 years after a tick bite. An increased serum antibody titer to Borrelia burgdorferi suggested a diagnosis of Lyme neuroborreliosis, although a concomitant cervical spondylosis probably contributed to spinal cord damage. Treatment with ceftriaxone resulted in a marked improvement of neuropathic symptoms, providing indirect evidence of spirochetal infection. Search for B. burgdorferi DNA by polymerase chain reaction amplification on sural nerve confirmed the diagnosis, demonstrating that the spirochete localized in the peripheral nervous system. The presence of complement membrane attack complex deposits and macrophage infiltrates around epineurial vessels and within the endoneurium suggests that the neuropathy in our patient was immune-mediated.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/8456
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