Concentrations of interleukin 2 receptor (sIL-2R) have been suggested as a marker of rejection episodes after organ transplantation. To evaluate the analytical performance of a ''sandwich-type'' enzyme immunoassay method for sIL-2R and to verify whether increased concentrations of sIL-2R might be a useful marker of allograft rejection, we quantified sIL-2R in serum samples from heart- or kidney-transplant patients. The mean (±SD) pre-transplant value of sIL-2R (592 ± 209 kilo-units/L) in heart-transplant patients was significantly higher (P <0.01) than that observed in controls (350 ± 101 kilo-units/L). After heart transplantation, the concentrations of sIL-2R slowly decreased to baseline in successfully treated patients but increased significantly (1129 ± 215 kilo-units/L; P [removed]
Zucchelli, G.C., Clerico, A., De Maria, R., Carmellini, M., Di Stefano, R., Masini, S., et al. (1990). Increased Circulating Concentrations of Interleukin 2 Receptor during Rejection Episodes in Heart or Kidney Transplant Recipients. CLINICAL CHEMISTRY, 36(12), 2106-2109 [10.1093/clinchem/36.12.2106].
Increased Circulating Concentrations of Interleukin 2 Receptor during Rejection Episodes in Heart or Kidney Transplant Recipients
Carmellini, M.;
1990-01-01
Abstract
Concentrations of interleukin 2 receptor (sIL-2R) have been suggested as a marker of rejection episodes after organ transplantation. To evaluate the analytical performance of a ''sandwich-type'' enzyme immunoassay method for sIL-2R and to verify whether increased concentrations of sIL-2R might be a useful marker of allograft rejection, we quantified sIL-2R in serum samples from heart- or kidney-transplant patients. The mean (±SD) pre-transplant value of sIL-2R (592 ± 209 kilo-units/L) in heart-transplant patients was significantly higher (P <0.01) than that observed in controls (350 ± 101 kilo-units/L). After heart transplantation, the concentrations of sIL-2R slowly decreased to baseline in successfully treated patients but increased significantly (1129 ± 215 kilo-units/L; P [removed]
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https://hdl.handle.net/11365/8410
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