Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89% respectively.

Perissutti, E., Fiorino, F., Severino, B., Frecentese, F., Massarelli, P., Nencini, C., et al. (2007). Synthesis of 6beta-D-glucosyl and 6-nitroxy(-)-galanthamine derivatives as acetylcholinesterase inhibitors. PHARMAZIE, 62(6), 403-405 [10.1691/ph.2007.6.6661].

Synthesis of 6beta-D-glucosyl and 6-nitroxy(-)-galanthamine derivatives as acetylcholinesterase inhibitors

MASSARELLI P.;NENCINI C.;
2007-01-01

Abstract

Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89% respectively.
2007
Perissutti, E., Fiorino, F., Severino, B., Frecentese, F., Massarelli, P., Nencini, C., et al. (2007). Synthesis of 6beta-D-glucosyl and 6-nitroxy(-)-galanthamine derivatives as acetylcholinesterase inhibitors. PHARMAZIE, 62(6), 403-405 [10.1691/ph.2007.6.6661].
File in questo prodotto:
File Dimensione Formato  
118184_UPLOAD.pdf

non disponibili

Tipologia: PDF editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 90.13 kB
Formato Adobe PDF
90.13 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/8360
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo