Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89% respectively.

Perissutti, E., Fiorino, F., Severino, B., Frecentese, F., Massarelli, P., Nencini, C., et al. (2007). Synthesis of 6beta-D-glucosyl and 6-nitroxy(-)-galanthamine derivatives as acetylcholinesterase inhibitors. PHARMAZIE, 62(6), 403-405 [10.1691/ph.2007.6.6661].

Synthesis of 6beta-D-glucosyl and 6-nitroxy(-)-galanthamine derivatives as acetylcholinesterase inhibitors

MASSARELLI, PAOLA;NENCINI, CRISTINA;
2007

Abstract

Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89% respectively.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/8360
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