Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89% respectively.
Perissutti, E., Fiorino, F., Severino, B., Frecentese, F., Massarelli, P., Nencini, C., et al. (2007). Synthesis of 6beta-D-glucosyl and 6-nitroxy(-)-galanthamine derivatives as acetylcholinesterase inhibitors. PHARMAZIE, 62(6), 403-405 [10.1691/ph.2007.6.6661].
Synthesis of 6beta-D-glucosyl and 6-nitroxy(-)-galanthamine derivatives as acetylcholinesterase inhibitors
MASSARELLI, PAOLA;NENCINI, CRISTINA;
2007-01-01
Abstract
Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89% respectively.
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https://hdl.handle.net/11365/8360
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