This study reports the ability to settle of commercial pharmaceutical grade starch samples, both native and pregelatinized. The experiments were carried out under different relative humidity (RH%) conditions and the packing properties were evaluated using both official pharmacopoeial monograph conditions and also modified conditions in order to give a deeper knowledge of tapping under mild mechanical stress. The technique adopted, simulating common pharmaceutical operating practices, appears to be useful to estimate some technologically relevant features of diluent powder materials. Moreover, a general mathematical function has been applied to the experimental data; this could be appropriate for adequately describing material settling patterns and offers practical parameters for characterizing starch powders within the context of a pharmaceutical quality system.

Zanardi, I., Gabbrielli, A., & Travagli, V. (2009). Packing properties of starch-based powders under mild mechanical solicitation. PHARMAZIE, 64, 440-444 [10.1691/ph.2009.8297].

Packing properties of starch-based powders under mild mechanical solicitation

ZANARDI, IACOPO;GABBRIELLI, ALESSANDRO;TRAVAGLI, VALTER
2009

Abstract

This study reports the ability to settle of commercial pharmaceutical grade starch samples, both native and pregelatinized. The experiments were carried out under different relative humidity (RH%) conditions and the packing properties were evaluated using both official pharmacopoeial monograph conditions and also modified conditions in order to give a deeper knowledge of tapping under mild mechanical stress. The technique adopted, simulating common pharmaceutical operating practices, appears to be useful to estimate some technologically relevant features of diluent powder materials. Moreover, a general mathematical function has been applied to the experimental data; this could be appropriate for adequately describing material settling patterns and offers practical parameters for characterizing starch powders within the context of a pharmaceutical quality system.
Zanardi, I., Gabbrielli, A., & Travagli, V. (2009). Packing properties of starch-based powders under mild mechanical solicitation. PHARMAZIE, 64, 440-444 [10.1691/ph.2009.8297].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/8313
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