The ability to settle and the tribological properties of three samples of pregelatinized starch widely available commercially were investigated with reference to their technological implications. In particular, we evaluated the influence of storage conditions, storage time, moisture content, equipment, handling, and mechanical treatment on the apparent volume, poured density and tapped density, as well as on tests of flow parameters such as basic flowability energy. The results obtained highlight the fact that the technologically relevant behaviour of pregelatinized starches in terms of apparent volume and tribological properties may be influenced not only by relative humidity (RH%) conditions, but also by common pharmaceutical operating practices. In particular, previous mechanical treatment can lead to statistically different behaviour in tests of ability to settle according to pharmacopoeial specifications, depending on both RH% conditioning and the amount of powder, although the materials under investigation all conform to the respective monograph in the Pharmacopoeia. All these aspects are of special interest with regard to the various pharmaceutical formulations which include pregelatinized starch, both on an industrial scale and in small-scale production.

Travagli, V., Zanardi, I. (2007). Commercial pregelatinized starches: ability to settle and rheological evaluation. PHARMAZIE, 62(9), 683-688 [10.1691/ph.2007.9.6265].

Commercial pregelatinized starches: ability to settle and rheological evaluation

Travagli, Valter;Zanardi, Iacopo
2007-01-01

Abstract

The ability to settle and the tribological properties of three samples of pregelatinized starch widely available commercially were investigated with reference to their technological implications. In particular, we evaluated the influence of storage conditions, storage time, moisture content, equipment, handling, and mechanical treatment on the apparent volume, poured density and tapped density, as well as on tests of flow parameters such as basic flowability energy. The results obtained highlight the fact that the technologically relevant behaviour of pregelatinized starches in terms of apparent volume and tribological properties may be influenced not only by relative humidity (RH%) conditions, but also by common pharmaceutical operating practices. In particular, previous mechanical treatment can lead to statistically different behaviour in tests of ability to settle according to pharmacopoeial specifications, depending on both RH% conditioning and the amount of powder, although the materials under investigation all conform to the respective monograph in the Pharmacopoeia. All these aspects are of special interest with regard to the various pharmaceutical formulations which include pregelatinized starch, both on an industrial scale and in small-scale production.
2007
Travagli, V., Zanardi, I. (2007). Commercial pregelatinized starches: ability to settle and rheological evaluation. PHARMAZIE, 62(9), 683-688 [10.1691/ph.2007.9.6265].
File in questo prodotto:
File Dimensione Formato  
Pharmazie 2007 683-688.pdf

non disponibili

Tipologia: PDF editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 118.27 kB
Formato Adobe PDF
118.27 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/8309
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo