Ctxs are a family of α-helical, cationic, 3 kDa antibacterial peptides secreted by the female reproductive accessory glands of the Mediterranean fruit fly Ceratitis capitata. These peptides were found to display strong antibacterial activity and weak hemolytic activity. When reconstituted into planar lipid bilayers chemically synthesized Ctxs formed voltage-dependent ion channels according to the barrel-stave model. A synthetic truncated CtxA molecule resulted to permeabilize the outer and inner membranes of Escherichia coli cells.
Marchini, D., Marri, L. (2010). Ceratotoxins, antibacterial sex-specific peptides from the medfly Ceratitis capitata. CURRENT TOPICS IN PEPTIDE & PROTEIN RESEARCH, 11, 31-36.
Ceratotoxins, antibacterial sex-specific peptides from the medfly Ceratitis capitata.
MARCHINI, DANIELA;MARRI, LAURA
2010-01-01
Abstract
Ctxs are a family of α-helical, cationic, 3 kDa antibacterial peptides secreted by the female reproductive accessory glands of the Mediterranean fruit fly Ceratitis capitata. These peptides were found to display strong antibacterial activity and weak hemolytic activity. When reconstituted into planar lipid bilayers chemically synthesized Ctxs formed voltage-dependent ion channels according to the barrel-stave model. A synthetic truncated CtxA molecule resulted to permeabilize the outer and inner membranes of Escherichia coli cells.
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https://hdl.handle.net/11365/8243
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