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Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, blaOXA-24 was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism. Copyright © 2009, American Society for Microbiology. All Rights Reserved.

D'Andrea, M.M., Giani, T., D'Arezzo, S., Capone, A., Petrosillo, N., Visca, P., et al. (2009). Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 53(8), 3528-3533 [10.1128/AAC.00178-09].

Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii

D'ANDREA M. M.;GIANI T.;
2009-01-01

Abstract

Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, blaOXA-24 was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
2009
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
D'Andrea, M.M., Giani, T., D'Arezzo, S., Capone, A., Petrosillo, N., Visca, P., et al. (2009). Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 53(8), 3528-3533 [10.1128/AAC.00178-09].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/7969
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