A new natural TEM derivative with extended-spectrum β-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The blaTEM-134 gene was not transferable by conjugation and, apparently, was chromosomally encoded. Expression studies with Escherichia coli revealed efficient cefotaximase and ceftazidimase activity for TEM-134.

Perilli, M., Mugnaioli, C., Luzzaro, F., Fiore, M., Stefani, S., Rossolini, G.M., et al. (2005). Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 49(4), 1564-1566 [10.1128/AAC.49.4.1564-1566.2005].

Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate.

ROSSOLINI, GIAN MARIA;
2005

Abstract

A new natural TEM derivative with extended-spectrum β-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The blaTEM-134 gene was not transferable by conjugation and, apparently, was chromosomally encoded. Expression studies with Escherichia coli revealed efficient cefotaximase and ceftazidimase activity for TEM-134.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/7907
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