T cell priming is a critical event in the initiation of the immune response to vaccination since it deeply influences both the magnitude and the quality of the immune response induced. CD4+ T cell priming, required for the induction of high-affinity antibodies and immune memory, represents a key target for improving and modulating vaccine immunogenicity. A major challenge in the study of in vivo T cell priming is due to the low frequency of antigen-specific T cells. This review discusses the current knowledge on antigen-specific CD4+ T cell priming in the context of vaccination, as well as the most advanced tools for the characterization of the in vivo T cell priming and the opportunities offered by the application of systems biology. © 2013 Ciabattini, Pettini and Medaglini.

Ciabattini, A., Pettini, E., & Medaglini, D. (2013). CD4+ T Cell Priming as Biomarker to Study Immune Response to Preventive Vaccines. FRONTIERS IN IMMUNOLOGY, 4, 1-10 [10.3389/fimmu.2013.00421].

CD4+ T Cell Priming as Biomarker to Study Immune Response to Preventive Vaccines

Annalisa Ciabattini;Elena Pettini;Donata Medaglini
2013

Abstract

T cell priming is a critical event in the initiation of the immune response to vaccination since it deeply influences both the magnitude and the quality of the immune response induced. CD4+ T cell priming, required for the induction of high-affinity antibodies and immune memory, represents a key target for improving and modulating vaccine immunogenicity. A major challenge in the study of in vivo T cell priming is due to the low frequency of antigen-specific T cells. This review discusses the current knowledge on antigen-specific CD4+ T cell priming in the context of vaccination, as well as the most advanced tools for the characterization of the in vivo T cell priming and the opportunities offered by the application of systems biology. © 2013 Ciabattini, Pettini and Medaglini.
Ciabattini, A., Pettini, E., & Medaglini, D. (2013). CD4+ T Cell Priming as Biomarker to Study Immune Response to Preventive Vaccines. FRONTIERS IN IMMUNOLOGY, 4, 1-10 [10.3389/fimmu.2013.00421].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/746240