It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signaling molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS. It has been demonstrated that a specific μ-opiate-receptor subtype, μ3, mediates these downregulatory effects through release of NO. This article examines morphine as an endogenous signaling molecule, in terms of its role in neural and immune regulation.
|Citazione:||Stefano, G.b., Goumon, Y., Casares, F., Cadet, P., Fricchione, G.l., Rialas, C., et al. (2000). Endogenous morphine. TRENDS IN NEUROSCIENCES, 23(9), 436-442.|
|Appare nelle tipologie:||1.1 Articolo in rivista|