Glutathione (GSH) plays a critical role in protection liver against injury produced by electrophilic metabolites deriving from acetaminophen (APAP), drug which is able to alkyate vital nucleophilic sites of macromolecules. The amount of GSH avaible for coniugate formation and the ability to resynthesize the GSH consumed by detoxification of rezctive intermediates, are determinant keys of the extent of hepatic necrosis produced by APAP.
Micheli, L., Giorgi, G. (1988). Variation of glutathione levels in liver of rats induced by acetaminophen. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 20(5), 427-428 [10.1016/S0031-6989(88)80026-2].
Variation of glutathione levels in liver of rats induced by acetaminophen
MICHELI, LUCIA;GIORGI, GIORGIO
1988-01-01
Abstract
Glutathione (GSH) plays a critical role in protection liver against injury produced by electrophilic metabolites deriving from acetaminophen (APAP), drug which is able to alkyate vital nucleophilic sites of macromolecules. The amount of GSH avaible for coniugate formation and the ability to resynthesize the GSH consumed by detoxification of rezctive intermediates, are determinant keys of the extent of hepatic necrosis produced by APAP.
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https://hdl.handle.net/11365/508000