Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [wzi154, producing KPC-3])
Monaco, M., Giani, T., Raffone, M., Arena, F., Garcia Fernandez, A., Pollini, S., et al. (2014). Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014. EUROSURVEILLANCE, 19(42), Art. id 20939.
Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014.
GIANI, TOMMASO;ARENA, FABIO;POLLINI, SIMONA;ROSSOLINI, GIAN MARIA;
2014-01-01
Abstract
Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [wzi154, producing KPC-3])I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/48815
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