Indolent non-Hodgkin lymphomas (iNHLs) are B-cell neoplasms for which no consensus is available about optimal first-line therapy. Chemoimmunotherapy with fludarabine, cyclophospamide and rituximab is very effective, but may give severe hematological and non-hematological toxicity at standard doses, especially in elderly patients. In this phase II study, 25 untreated elderly patients with iNHL received rituximab (375 mg/m2 ) plus low-dose oral fludarabine (25 mg/ m2 for 4 consecutive days) and cyclophosphamide (150 mg/m2 for 4 consecutive days) for four monthly cycles. Twenty-three patients were responsive (92%) and 12 patients achieved a complete remission (48%). Twenty-one patients (84%) were alive, median follow-up was 30 months and median event-free survival (EFS) was not reached. Patients who we previously treated with chemotherapy alone had a shorter EFS (median 20 months). Compliance was good, with mild toxicity. This regimen is effective for elderly patients with iNHL. The addition of rituximab results in long EFS without affecting toxicity.

Fabbri, A., Cencini, E., Rigacci, L., Bartalucci, G., Puccini, B., Dottori, R., et al. (2014). Efficacy and safety of rituximab plus low-dose oral fludarabine and cyclophosphamide as first-line treatment of elderly patients with indolent non-Hodgkin lymphomas. LEUKEMIA & LYMPHOMA, 55(4), 781-785 [10.3109/10428194.2013.826354].

Efficacy and safety of rituximab plus low-dose oral fludarabine and cyclophosphamide as first-line treatment of elderly patients with indolent non-Hodgkin lymphomas

CENCINI, EMANUELE;Gozzetti A;BOCCHIA, MONICA
2014

Abstract

Indolent non-Hodgkin lymphomas (iNHLs) are B-cell neoplasms for which no consensus is available about optimal first-line therapy. Chemoimmunotherapy with fludarabine, cyclophospamide and rituximab is very effective, but may give severe hematological and non-hematological toxicity at standard doses, especially in elderly patients. In this phase II study, 25 untreated elderly patients with iNHL received rituximab (375 mg/m2 ) plus low-dose oral fludarabine (25 mg/ m2 for 4 consecutive days) and cyclophosphamide (150 mg/m2 for 4 consecutive days) for four monthly cycles. Twenty-three patients were responsive (92%) and 12 patients achieved a complete remission (48%). Twenty-one patients (84%) were alive, median follow-up was 30 months and median event-free survival (EFS) was not reached. Patients who we previously treated with chemotherapy alone had a shorter EFS (median 20 months). Compliance was good, with mild toxicity. This regimen is effective for elderly patients with iNHL. The addition of rituximab results in long EFS without affecting toxicity.
Fabbri, A., Cencini, E., Rigacci, L., Bartalucci, G., Puccini, B., Dottori, R., et al. (2014). Efficacy and safety of rituximab plus low-dose oral fludarabine and cyclophosphamide as first-line treatment of elderly patients with indolent non-Hodgkin lymphomas. LEUKEMIA & LYMPHOMA, 55(4), 781-785 [10.3109/10428194.2013.826354].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/47388
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