PAR(2) , but not TLR4, expression was enhanced in aortas of endotoxaemic rats. PAR(2) AP-induced vasorelaxation was increased in aortic rings of LPS-treated rats. TLR4 inhibitors, curcumine and resveratrol, reduced PAR(2) AP-induced vasorelaxation and PAR(2) AP-induced hypotension in both naïve and endotoxaemic rats. Finally, in aortic rings from TLR4(-/-) mice, the expression of PAR(2) was reduced and the PAR(2) AP-induced vasodilatation impaired compared with those from wild-type mice and both resveratrol and curcumine were ineffective.Cross-talk between PAR(2) and TLR4 contributes to vascular homeostasis.
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|Titolo:||Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR2) is involved in vascular function.|
|Citazione:||M., B., V., V., I., H., V., B., F., R., G., M.R., et al. (2013). Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR2) is involved in vascular function. BRITISH JOURNAL OF PHARMACOLOGY, 168(2), 411-420.|
|Appare nelle tipologie:||1.1 Articolo in rivista|