Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans. © 2013 Elsevier Ltd. All rights reserved.
Galano, J.M., Mas, E., Barden, A., Mori, T.A., Signorini, C., De Felice, C., et al. (2013). Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans. PROSTAGLANDINS & OTHER LIPID MEDIATORS, 107, 95-102 [10.1016/j.prostaglandins.2013.04.003].
Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans
Signorini, C.;
2013-01-01
Abstract
Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans. © 2013 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/46438
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