Abstract. BACKGROUND: Botulinum neurotoxin A (BoNT-A) may reduce lower limb spasticity but its role in improving walking ability remains to be established. OBJECTIVE: To investigate the efficacy of simultaneous BoNT-A injections into several targeted spastic muscles of different joints on gait speed and on functional gains in gait performance in chronic stroke and MS patients. METHODS: Twenty patients affected by stroke or multiple sclerosis were tested before, one and three months after BoNTA administration. Gait was evaluated by the 10 Meter Walk Test; patients were stratified into functional ambulation classes accordingly. Spasticity was assessed using the modified Ashworth Scale. RESULTS: At final assessment, spasticity was reduced in hip adductors and ankle plantar-flexors, gait speed improved and, 1/3rd of patients transitioned to a higher ambulation class. The pre-post difference in Level of Spasticity of the hips was a predictor for an increase in gait speed. CONCLUSIONS: A meaningful improvement in walking performance can be obtained in chronic spastic patients after BoNT-A injection into several muscles, specifically the hip adductors.
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|Titolo:||Meaningful improvement in walking performance after botulinum neurotoxin A (BoNT-A) in chronic spastic patients.|
|Citazione:||Cioncoloni, D., Taddei, S., Bielli, S., Annunziata, P., & Mazzocchio, R. (2014). Meaningful improvement in walking performance after botulinum neurotoxin A (BoNT-A) in chronic spastic patients. NEUROREHABILITATION, 34, 185-192.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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