PVA based hydrogel was synthesised using, as crosslinking agent, trisodium trimetaphosphate (STMP) and its morphology was modified inducing a microporous structure to obtain potential substitutes for cartilage tissue. The hydrogel was characterised by Infrared Spectroscopy combined with Time of flight mass spectrometry (ToF-SIMS) that confirmed the successful occurrence of crosslinking reaction, the hyphotised crosslinking arm and its homogeneous distribution. The mechanical spectra of the fully hydrated samples confirmed covalently crosslinked systems with a rheological behaviour similar to that of tibial cartilage. Further analysis in terms of water content measurements, thermal stability and cytotoxicity confirmed the applicability of such a hydrogel as cartilage substitute.
Leone, G., Bidini, A., Lamponi, S., Magnani, A. (2013). States of water, surface and rheological characterisation of a new biohydrogel as articular cartilage substitute. POLYMERS FOR ADVANCED TECHNOLOGIES, 24(9), 824-833 [10.1002/pat.3150].
States of water, surface and rheological characterisation of a new biohydrogel as articular cartilage substitute
Leone, Gemma;Lamponi, Stefania;Magnani, Agnese
2013-01-01
Abstract
PVA based hydrogel was synthesised using, as crosslinking agent, trisodium trimetaphosphate (STMP) and its morphology was modified inducing a microporous structure to obtain potential substitutes for cartilage tissue. The hydrogel was characterised by Infrared Spectroscopy combined with Time of flight mass spectrometry (ToF-SIMS) that confirmed the successful occurrence of crosslinking reaction, the hyphotised crosslinking arm and its homogeneous distribution. The mechanical spectra of the fully hydrated samples confirmed covalently crosslinked systems with a rheological behaviour similar to that of tibial cartilage. Further analysis in terms of water content measurements, thermal stability and cytotoxicity confirmed the applicability of such a hydrogel as cartilage substitute.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/45035
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