PVA based hydrogel was synthesised using, as crosslinking agent, trisodium trimetaphosphate (STMP) and its morphology was modified inducing a microporous structure to obtain potential substitutes for cartilage tissue. The hydrogel was characterised by Infrared Spectroscopy combined with Time of flight mass spectrometry (ToF-SIMS) that confirmed the successful occurrence of crosslinking reaction, the hyphotised crosslinking arm and its homogeneous distribution. The mechanical spectra of the fully hydrated samples confirmed covalently crosslinked systems with a rheological behaviour similar to that of tibial cartilage. Further analysis in terms of water content measurements, thermal stability and cytotoxicity confirmed the applicability of such a hydrogel as cartilage substitute.
|Titolo:||States of water, surface and rheological characterisation of a new biohydrogel as articular cartilage substitute|
|Citazione:||Leone, G., Bidini, A., Lamponi, S., & Magnani, A. (2013). States of water, surface and rheological characterisation of a new biohydrogel as articular cartilage substitute. POLYMERS FOR ADVANCED TECHNOLOGIES, 24, 824-833.|
|Appare nelle tipologie:||1.1 Articolo in rivista|