High intrathecal levels of anti-myelin basic protein (MBP) IgM were previously found to be significantly associated with early favorable course in a cohort of patients with multiple sclerosis (MS). A mAb to MBP 105-120 recognizing the 222-228 epitope of the extracellular domain of high affinity immunoglobulin gamma Fc-receptor I (CD64) was isolated from EBV(+) B cell clones of long-term stable RRMS patients. This mAb exerted immunosuppressive activity on MS-derived T cell lines through induction and release of high amounts of interleukin-10 and decreased levels of interleukin-12 from activated monocytes providing the biological basis for a potential new treatment for MS and other immune-mediated neurological disorders.

Annunziata, P., Cioni, C., Cantalupo, L., DI GENOVA, G., GORI SAVELLINI, G., & Cusi, M.G. (2013). Immunosuppressive monoclonal antibody to CD64 from patients with long-term stable multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, 256(1-2), 62-70 [10.1016/j.jneuroim.2012.12.007].

Immunosuppressive monoclonal antibody to CD64 from patients with long-term stable multiple sclerosis.

ANNUNZIATA, PASQUALE;CIONI, CHIARA;GORI SAVELLINI G.;CUSI, MARIA GRAZIA
2013

Abstract

High intrathecal levels of anti-myelin basic protein (MBP) IgM were previously found to be significantly associated with early favorable course in a cohort of patients with multiple sclerosis (MS). A mAb to MBP 105-120 recognizing the 222-228 epitope of the extracellular domain of high affinity immunoglobulin gamma Fc-receptor I (CD64) was isolated from EBV(+) B cell clones of long-term stable RRMS patients. This mAb exerted immunosuppressive activity on MS-derived T cell lines through induction and release of high amounts of interleukin-10 and decreased levels of interleukin-12 from activated monocytes providing the biological basis for a potential new treatment for MS and other immune-mediated neurological disorders.
Annunziata, P., Cioni, C., Cantalupo, L., DI GENOVA, G., GORI SAVELLINI, G., & Cusi, M.G. (2013). Immunosuppressive monoclonal antibody to CD64 from patients with long-term stable multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, 256(1-2), 62-70 [10.1016/j.jneuroim.2012.12.007].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/44643
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