The 2-substituted 1,4-benzodiazepines (4 and 6) were synthesized. The reaction of 2-aminobenzophenone oximes with ethyl 4-chloroacetoacetate gave the 1,4-benzodiazepines (4) and the 1,2-dihydroquinazolines (5); the latter were treated with a base to result ring expansion giving the 1,4-benzodiazepines (6).
Anzini, M., Garofalo, A., Vomero, S. (1989). Synthesis of Functionalized Derivatives of Quinazolines and 1,4-Benzodiazepines. HETEROCYCLES, 29(8), 1477-1487 [10.3987/COM-89-4933].
Synthesis of Functionalized Derivatives of Quinazolines and 1,4-Benzodiazepines
ANZINI, M.;
1989-01-01
Abstract
The 2-substituted 1,4-benzodiazepines (4 and 6) were synthesized. The reaction of 2-aminobenzophenone oximes with ethyl 4-chloroacetoacetate gave the 1,4-benzodiazepines (4) and the 1,2-dihydroquinazolines (5); the latter were treated with a base to result ring expansion giving the 1,4-benzodiazepines (6).
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https://hdl.handle.net/11365/44590
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