Human placenta produces a large variety of bioactive substances with endocrine and neural competence: pituitary and gonadal hormones, hypothalamic-like releasing or inhibiting hormones, growth factors, cytokines and neuropeptides. The most recent findings indicate that locally produced hormones regulate the secretion of other placental hormones supporting a paracrine/autocrine regulation. In placental endocrinology, a particular relevance is played by steroid hormones. In fact, a specific gonadotropin-releasing hormone (GnRH)-human chorionic gonadotropin (hCG) regulation of placental steroidogenesis has been proposed as a placental internal regulatory system acting on steroids production from human placenta. In addition, activin and inhibin have been proposed as further regulatory substances of the synthesis and secretion of steroids; the addition of activin A to placental culture augments GnRH, hCG and progesterone, and this effect can be significantly reduced by the addition of inhibins. Finally, a steroid-steroid interaction is suggested by the evidence that placental estrogen has a positive role in the regulation of progesterone biosynthesis. Other steroid-protein interactions have been observed in human placenta. In fact, recent data indicate that progesterone inhibits placental corticotropin-releasing factor (CRF) and estrogens act on placental conversion of cortisol to cortisone, activating cortisol secretion by the fetal adrenal and enhancing fetal adrenal function with advancing gestation.
Petraglia, F., A. A., D.M., Florio, P., M., S., A., G., V., C., et al. (1995). Steroid-protein interaction in human placenta. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 53, 227-231.
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|Titolo:||Steroid-protein interaction in human placenta.|
|Citazione:||Petraglia, F., A. A., D.M., Florio, P., M., S., A., G., V., C., et al. (1995). Steroid-protein interaction in human placenta. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 53, 227-231.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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