A randomised double-blind multicentre clinical trial was carried out to verify the effectiveness and tolerance of S-adenosylmethionine (SAMe) versus ibuprofen in 150 patients with hip and/or knee osteoarthritis. Both drugs were given orally 400 mg t.i.d. for 30 days. SAMe exhibited a slightly more marked activity than the reference drug in the management of the various painful manifestations of the joint disease. Minor side effects developed in 5 patients of SAMe group, and in 16 patients of ibuprofen group. No drop-outs occurred. No changes were observed in the routine laboratory tests.
Marcolongo, R., Giordano, N., Colombo, B. (1985). Double-blind multicenter study of the activity of S-adenosyl-methionine in hip and knee osteoarthritis. CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 37(1), 82-94.
Double-blind multicenter study of the activity of S-adenosyl-methionine in hip and knee osteoarthritis
Giordano, N.;
1985-01-01
Abstract
A randomised double-blind multicentre clinical trial was carried out to verify the effectiveness and tolerance of S-adenosylmethionine (SAMe) versus ibuprofen in 150 patients with hip and/or knee osteoarthritis. Both drugs were given orally 400 mg t.i.d. for 30 days. SAMe exhibited a slightly more marked activity than the reference drug in the management of the various painful manifestations of the joint disease. Minor side effects developed in 5 patients of SAMe group, and in 16 patients of ibuprofen group. No drop-outs occurred. No changes were observed in the routine laboratory tests.
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https://hdl.handle.net/11365/43431
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