Forty out-patients with rheumatoid arthritis took part in a double-blind crossover trial to compare the short-term effectiveness and safety of two formulations of oral ketoprofen, i.e., plain and slow-release capsules, each given for one week without any interval between treatments. The daily dosage, 300 mg in both cases, was split in, respectively, three and two doses. Significant improvements were found in all variables studied (pain at rest, pain on active motion, quality of sleep, duration of morning stiffness, grip strength, Ritchie's articular index) with both regimens, but no significant differences were detected between them. The patients' estimates of the overall response to the two treatments coincided. Adverse reactions were limited to mild pyrosis in one patient who was receiving plain ketoprofen. The results of the present trial are consistent with previous findings in osteoarthritic patients, indicating that the two formulations are virtually equivalent in use.
Marcolongo, R., Giordano, N., Fioravanti, A. (1984). Clinical pharmacology of a slow-release ketoprofen preparation: a double-blind, crossover comparison with plain ketoprofen in rheumatoid arthritis. CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 35(5), 721-726.
Clinical pharmacology of a slow-release ketoprofen preparation: a double-blind, crossover comparison with plain ketoprofen in rheumatoid arthritis
Giordano N.;
1984-01-01
Abstract
Forty out-patients with rheumatoid arthritis took part in a double-blind crossover trial to compare the short-term effectiveness and safety of two formulations of oral ketoprofen, i.e., plain and slow-release capsules, each given for one week without any interval between treatments. The daily dosage, 300 mg in both cases, was split in, respectively, three and two doses. Significant improvements were found in all variables studied (pain at rest, pain on active motion, quality of sleep, duration of morning stiffness, grip strength, Ritchie's articular index) with both regimens, but no significant differences were detected between them. The patients' estimates of the overall response to the two treatments coincided. Adverse reactions were limited to mild pyrosis in one patient who was receiving plain ketoprofen. The results of the present trial are consistent with previous findings in osteoarthritic patients, indicating that the two formulations are virtually equivalent in use.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/43430
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