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Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.

Theys, K., Vercauteren, J., Snoeck, J., Zazzi, M., Camacho, R.J., Torti, C., et al. (2013). HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(2), 1053-1056 [10.1128/AAC.01668-12].

HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir

Zazzi, M.;
2013-01-01

Abstract

Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.
2013
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Theys, K., Vercauteren, J., Snoeck, J., Zazzi, M., Camacho, R.J., Torti, C., et al. (2013). HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(2), 1053-1056 [10.1128/AAC.01668-12].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/43362
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