Free radical excess and oxidative stress are implicated in the formation and progression of atherosclerotic plaque through actions on susceptible vascular cells, such as by activating xanthine oxidase. Purine bases and other antioxidant compounds could play important protective roles in atherogenesis, as could nonenzymatic low molecular weight thiol defenses, not previously evaluated in carotid artery plaque. Therefore, we measured purine catabolites (hypoxanthine, xanthine, uric acid, allantoin) and antioxidant compounds (total sulphydryl groups, homocysteine, cysteine, and glutathione) in advanced carotid artery plaque and found a high ratio of allantoin to uric acid, suggesting a ongoing local oxidative stress

Ciari, I., Terzuoli, L., Porcelli, B., Coppola, M.G., Marinello, E. (2008). Antioxidant status and purine bases in carotid artery plaque. NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, 27(6-7), 624-627 [10.1080/15257770802138608].

Antioxidant status and purine bases in carotid artery plaque

TERZUOLI L.;PORCELLI B.;
2008-01-01

Abstract

Free radical excess and oxidative stress are implicated in the formation and progression of atherosclerotic plaque through actions on susceptible vascular cells, such as by activating xanthine oxidase. Purine bases and other antioxidant compounds could play important protective roles in atherogenesis, as could nonenzymatic low molecular weight thiol defenses, not previously evaluated in carotid artery plaque. Therefore, we measured purine catabolites (hypoxanthine, xanthine, uric acid, allantoin) and antioxidant compounds (total sulphydryl groups, homocysteine, cysteine, and glutathione) in advanced carotid artery plaque and found a high ratio of allantoin to uric acid, suggesting a ongoing local oxidative stress
2008
Ciari, I., Terzuoli, L., Porcelli, B., Coppola, M.G., Marinello, E. (2008). Antioxidant status and purine bases in carotid artery plaque. NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, 27(6-7), 624-627 [10.1080/15257770802138608].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/42295
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