This review focuses on the possibility of modifying hyaluronic acid by the insertion of sulfate groups in order to obtain heparin-like compounds with controllable properties. In particular, the physicochemical and biological behavior of sulfated hyaluronic acid (HyalSx) with various degrees of sulfation and different molecular weights has been particularly investigated. The mobilization of endothelial cells was investigated by the use of copper(II) complexes with HyalSx and the results were compared with those from the corresponding complex with heparin. New materials containing HyalSx are proposed for biomedical applications.

Magnani, A., Lamponi, S., Rappuoli, R., Barbucci, R. (1998). Sulphated Hyaluronic Acids : a Chemical and Biological Characterisation. POLYMER INTERNATIONAL, 46(3), 225-240 [10.1002/(SICI)1097-0126(199807)46:3<225::AID-PI45>3.0.CO;2-I].

Sulphated Hyaluronic Acids : a Chemical and Biological Characterisation

Magnani, Agnese;Lamponi, Stefania;Barbucci, Rolando
1998-01-01

Abstract

This review focuses on the possibility of modifying hyaluronic acid by the insertion of sulfate groups in order to obtain heparin-like compounds with controllable properties. In particular, the physicochemical and biological behavior of sulfated hyaluronic acid (HyalSx) with various degrees of sulfation and different molecular weights has been particularly investigated. The mobilization of endothelial cells was investigated by the use of copper(II) complexes with HyalSx and the results were compared with those from the corresponding complex with heparin. New materials containing HyalSx are proposed for biomedical applications.
1998
Magnani, A., Lamponi, S., Rappuoli, R., Barbucci, R. (1998). Sulphated Hyaluronic Acids : a Chemical and Biological Characterisation. POLYMER INTERNATIONAL, 46(3), 225-240 [10.1002/(SICI)1097-0126(199807)46:3<225::AID-PI45>3.0.CO;2-I].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/42257
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