Dermorphin, a naturally occurring heptapeptide that selectively binds to mu-opioid receptors, was injected intravenously 0.4 mg/kg in male rabbits. Eight days before injection the spontaneous behavior of the animals was observed in a neutral environment in the absence of external stimuli. At the same time, hippocampal EEG was recorded by telemetry. After dermorphin injection, the same experimental procedure was repeated. Behavior showed a strong increase in quiet immobility and a concomitant reduction in voluntary activities as compared to control periods. Treatment did not affect either the pattern or the frequency of hippocampal electrical activity.
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|Titolo:||Effect of dermorphin on behavior and hippocampal electrical activity in rabbits.|
|Citazione:||Fontani, G., Vergnani, L., Salvadori, S., Voglino, N., Aloisi, A.M., Portaluppi, F., et al. (1992). Effect of dermorphin on behavior and hippocampal electrical activity in rabbits. LIFE SCIENCES, 52, 323-328.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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