Dermorphin, a naturally occurring heptapeptide that selectively binds to mu-opioid receptors, was injected intravenously 0.4 mg/kg in male rabbits. Eight days before injection the spontaneous behavior of the animals was observed in a neutral environment in the absence of external stimuli. At the same time, hippocampal EEG was recorded by telemetry. After dermorphin injection, the same experimental procedure was repeated. Behavior showed a strong increase in quiet immobility and a concomitant reduction in voluntary activities as compared to control periods. Treatment did not affect either the pattern or the frequency of hippocampal electrical activity.
Fontani, G., Vergnani, L., Salvadori, S., Voglino, N., Alois, A., Portaluppi, F., et al. (1992). Effect of dermorphin on behavior and hippocampal electrical activity in rabbits. LIFE SCIENCES, 52(3), 323-328 [10.1016/0024-3205(93)90224-Q].
Effect of dermorphin on behavior and hippocampal electrical activity in rabbits
FONTANI, G.;
1992-01-01
Abstract
Dermorphin, a naturally occurring heptapeptide that selectively binds to mu-opioid receptors, was injected intravenously 0.4 mg/kg in male rabbits. Eight days before injection the spontaneous behavior of the animals was observed in a neutral environment in the absence of external stimuli. At the same time, hippocampal EEG was recorded by telemetry. After dermorphin injection, the same experimental procedure was repeated. Behavior showed a strong increase in quiet immobility and a concomitant reduction in voluntary activities as compared to control periods. Treatment did not affect either the pattern or the frequency of hippocampal electrical activity.
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https://hdl.handle.net/11365/4224
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