Components of the blood-brain barrier (BBB) include capillary endothelial cells, the vessel basement membrane (BM) and glial cell interface. While endothelial cell peculiarities are well known and thoroughly studied, BM morphology and functional properties are not. Vessel BM throughout the body is composed of laminin 1, the most common variant of laminin, which is made up of alpha 1, beta 1, and gamma 1 laminin chains, while cerebral vessel BM has been reported to also express the alpha 2 chain. In the present study, we show that the BM of newly formed vessels in brain tumors presents the same immunohistochemical structure as normal brain vessel BM, expressing alpha 1, alpha 2, beta 1, and gamma 1 laminin chains. The function of this particular vessel structure in the central nervous system is not yet completely understood; however, we hypothesize that vessel BM could play a role in impeding the extraneural spreading of brain tumors.
Toti, P., Villanova, M., De Felice, C., Megha, T., Bartolommei, S., Tosi, P. (1998). Expression of laminin 1 and 2 in brain tumor vessels. An immunohistochemical study. JOURNAL OF SUBMICROSCOPIC CYTOLOGY AND PATHOLOGY, 30(2), 227-230.
Expression of laminin 1 and 2 in brain tumor vessels. An immunohistochemical study
Toti, P.;Villanova, M.;Bartolommei, S.;Tosi, P.
1998-01-01
Abstract
Components of the blood-brain barrier (BBB) include capillary endothelial cells, the vessel basement membrane (BM) and glial cell interface. While endothelial cell peculiarities are well known and thoroughly studied, BM morphology and functional properties are not. Vessel BM throughout the body is composed of laminin 1, the most common variant of laminin, which is made up of alpha 1, beta 1, and gamma 1 laminin chains, while cerebral vessel BM has been reported to also express the alpha 2 chain. In the present study, we show that the BM of newly formed vessels in brain tumors presents the same immunohistochemical structure as normal brain vessel BM, expressing alpha 1, alpha 2, beta 1, and gamma 1 laminin chains. The function of this particular vessel structure in the central nervous system is not yet completely understood; however, we hypothesize that vessel BM could play a role in impeding the extraneural spreading of brain tumors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/41806
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