OBJECTIVE: To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates. SETTING: Six neonatal intensive care units (NICUs). PATIENTS: 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission. MAIN OUTCOME MEASURES: Positive and negative predictive values at different PCT cut-off levels. RESULTS: The overall probability of an NS was doubled or more if PCT was >0.5 ng/ml. In very-low-birth-weight (VLBW) infants, a cut-off of >2.4 ng/ml gave a positive predictive value of NS near to 50% with a probability of a false-positive diagnosis of NS in about 10% of the patients. CONCLUSIONS: In VLBW neonates, a serum PCT value >2.4 ng/ml prompts early empirical antibiotic therapy, while in normal-birth-weight infants, a PCT value ≤2.4 ng/ml carries a low risk of missing an NS

Auriti, C., Fiscarelli, E., Ronchetti, M.P., Argentieri, M., Marrocco, G., Quondamcarlo, A., et al. (2012). Procalcitonin in detecting neonatal nosocomial sepsis. ARCHIVES OF DISEASE IN CHILDHOOD. FETAL AND NEONATAL EDITION, 97(5), F368-F370 [10.1136/fetalneonatal-2010-194100].

Procalcitonin in detecting neonatal nosocomial sepsis

Bagnoli, F.;Buonocore, G.;
2012-01-01

Abstract

OBJECTIVE: To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates. SETTING: Six neonatal intensive care units (NICUs). PATIENTS: 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission. MAIN OUTCOME MEASURES: Positive and negative predictive values at different PCT cut-off levels. RESULTS: The overall probability of an NS was doubled or more if PCT was >0.5 ng/ml. In very-low-birth-weight (VLBW) infants, a cut-off of >2.4 ng/ml gave a positive predictive value of NS near to 50% with a probability of a false-positive diagnosis of NS in about 10% of the patients. CONCLUSIONS: In VLBW neonates, a serum PCT value >2.4 ng/ml prompts early empirical antibiotic therapy, while in normal-birth-weight infants, a PCT value ≤2.4 ng/ml carries a low risk of missing an NS
2012
Auriti, C., Fiscarelli, E., Ronchetti, M.P., Argentieri, M., Marrocco, G., Quondamcarlo, A., et al. (2012). Procalcitonin in detecting neonatal nosocomial sepsis. ARCHIVES OF DISEASE IN CHILDHOOD. FETAL AND NEONATAL EDITION, 97(5), F368-F370 [10.1136/fetalneonatal-2010-194100].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/40861
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