At present, little information is available on the genetics of common migraines, most likely to be considered a multifactorial disease. Recently, the CACNA1A gene encoding the brain-specific P/Q type calcium channel alpha(1) subunit, has been cloned and mutations in this gene, located on chromosome 19p13, have been shown to be involved in familial hemiplegic migraine (FHM), a rare autosomal dominantly inherited subtype of migraine with aura. Being part of the migraine spectrum, FHM represents a good model to study the genetics of more common forms of migraine. Different classes of mutations within the CACNA1A gene have been associated with different diseases, thus identifying a new member among 'channelopathies'. Variable clinical expression and genetic heterogeneity of FHM will be discussed.
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|Titolo:||Familial hemiplegic migraine: a ion channel disorder|
|Rivista:||BRAIN RESEARCH BULLETIN|
|Citazione:||Carrera, P., Stenirri, S., Ferrari, M., & Battistini, S. (2001). Familial hemiplegic migraine: a ion channel disorder. BRAIN RESEARCH BULLETIN, 56, 239-241.|
|Appare nelle tipologie:||1.1 Articolo in rivista|