The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds. © 2012 Elsevier Masson SAS. All rights reserved.
Biava, M., Battilocchio, C., Poce, G., Alfonso, S., Consalvi, S., Porretta, G.C., et al. (2012). Improving the Solubility of a New Class of Antiinflammatory Pharmacodynamic Hybrids, that Release Nitric Oxide and Inhibit Cycloxygenase-2 Isoenzyme. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 58, 287-298 [10.1016/j.ejmech.2012.10.014].
Improving the Solubility of a New Class of Antiinflammatory Pharmacodynamic Hybrids, that Release Nitric Oxide and Inhibit Cycloxygenase-2 Isoenzyme
Anzini, Maurizio
2012-01-01
Abstract
The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds. © 2012 Elsevier Masson SAS. All rights reserved.
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https://hdl.handle.net/11365/40153
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