Human exposure to polychlorobiphenyls (PCBs) in humans was determined by analyzing adipose tissue samples collected in 1996–1997 from two different localities: Siena (Italy) and Concepción (Chile). ΣPCBs was higher in Italian samples than that from Chile (493 and 53 ng/g wet wt., respectively). Thirty-seven different PCB congeners were identified in all samples. The prevailing PCB congeners in both groups were 22′44′5 pentachlorobiphenyl (IUPAC no. PCB 118), 22′344′5′ (PCB-138) and 22′44′55′ (PCB-153) hexachlorobiphenyls and 22′33′44′5 (PCB-170), 22′344′55′ (PCB-180) and 22′34′55′6 (PCB-187) heptachlorobiphenyls. PCB-153 accounted for more than 20% of the total PCB residue in both groups, while the remaining six congeners accounted for approximately 70%. Hexachlorobiphenyls were the most abundant congeners in all samples, with 42% of total residue in those from Italy and 43% in the Chilean samples, followed by heptachlorobiphenyls with 41 and 36% in Italian and Chilean samples, respectively. Average concentrations of non-ortho substituted coplanar congeners were below 1 pg/g wet wt. In the samples from Siena no noticeable differences were observed between the three average coplanar concentrations, while in those from Concepción 33′44′tetrachlorobiphenyl (PCB-77) was much higher than 33′44′pentachlorobiphenyl (PCB-126) and 33′44′55′hexachlorobiphenyl (PCB-169). For each sample the contribution to the total toxic equivalent values (ΣTEQs) of each non-ortho, mono-ortho and di-ortho substituted PCB congeners was assessed. The overall TEQs calculated for the monitored PCBs, were 10.16 pg/g wet wt. in Italian samples and 1.09 pg/g wet wt. in Chileans ones. In both groups the main contribution to ΣTEQs were the di-ortho substituted PCB congeners (Siena: 6.17 pg/g wet wt.; Concepción: 0.56 pg/g wet wt.) and the mono-ortho substituted PCB congeners (Siena: 3.97 pg/g wet wt.; Concepción: 0.50 pg/g wet wt.).

Mariottini, M., Focardi, S., & Aurigi, S. (2000). Congener profile and toxicity assessment of polychlorinated biphenyls in human adipose tissue of Italians and Chileans. MICROCHEMICAL JOURNAL, 67(1-3), 63-71 [10.1016/S0026-265X(00)00100-4].

Congener profile and toxicity assessment of polychlorinated biphenyls in human adipose tissue of Italians and Chileans

MARIOTTINI, M.;FOCARDI, S.;AURIGI, S.
2000

Abstract

Human exposure to polychlorobiphenyls (PCBs) in humans was determined by analyzing adipose tissue samples collected in 1996–1997 from two different localities: Siena (Italy) and Concepción (Chile). ΣPCBs was higher in Italian samples than that from Chile (493 and 53 ng/g wet wt., respectively). Thirty-seven different PCB congeners were identified in all samples. The prevailing PCB congeners in both groups were 22′44′5 pentachlorobiphenyl (IUPAC no. PCB 118), 22′344′5′ (PCB-138) and 22′44′55′ (PCB-153) hexachlorobiphenyls and 22′33′44′5 (PCB-170), 22′344′55′ (PCB-180) and 22′34′55′6 (PCB-187) heptachlorobiphenyls. PCB-153 accounted for more than 20% of the total PCB residue in both groups, while the remaining six congeners accounted for approximately 70%. Hexachlorobiphenyls were the most abundant congeners in all samples, with 42% of total residue in those from Italy and 43% in the Chilean samples, followed by heptachlorobiphenyls with 41 and 36% in Italian and Chilean samples, respectively. Average concentrations of non-ortho substituted coplanar congeners were below 1 pg/g wet wt. In the samples from Siena no noticeable differences were observed between the three average coplanar concentrations, while in those from Concepción 33′44′tetrachlorobiphenyl (PCB-77) was much higher than 33′44′pentachlorobiphenyl (PCB-126) and 33′44′55′hexachlorobiphenyl (PCB-169). For each sample the contribution to the total toxic equivalent values (ΣTEQs) of each non-ortho, mono-ortho and di-ortho substituted PCB congeners was assessed. The overall TEQs calculated for the monitored PCBs, were 10.16 pg/g wet wt. in Italian samples and 1.09 pg/g wet wt. in Chileans ones. In both groups the main contribution to ΣTEQs were the di-ortho substituted PCB congeners (Siena: 6.17 pg/g wet wt.; Concepción: 0.56 pg/g wet wt.) and the mono-ortho substituted PCB congeners (Siena: 3.97 pg/g wet wt.; Concepción: 0.50 pg/g wet wt.).
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/399008