We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.

DI GIAMBENEDETTO, S., Prosperi, M., Fanti, I., Bruzzone, B., Paolucci, S., Penco, G., et al. (2011). Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009. CLINICAL MICROBIOLOGY AND INFECTION, 17(9), 1352-1355 [10.1111/j.1469-0691.2011.03563.x].

Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009

M. ZAZZI;DE LUCA A
2011-01-01

Abstract

We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.
2011
DI GIAMBENEDETTO, S., Prosperi, M., Fanti, I., Bruzzone, B., Paolucci, S., Penco, G., et al. (2011). Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009. CLINICAL MICROBIOLOGY AND INFECTION, 17(9), 1352-1355 [10.1111/j.1469-0691.2011.03563.x].
File in questo prodotto:
File Dimensione Formato  
Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national databas.pdf

non disponibili

Tipologia: PDF editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 104.23 kB
Formato Adobe PDF
104.23 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/3939
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo