Plasma concentrations of troponin I (cTnI) provide useful descriptors of myocardial damage as an indicator of clinical outcome. Consequently, cTnI proffers a noninvasive index of potential donor organ dysfunction, reflecting the effectiveness of myocardial protection during the ischemic period and the degree of myocardial insult in the posttransplant recovery period. Assay of cTnI is typically performed for patients with unstable angina and acute coronary syndromes as a prognostic index7 to determine the need for aggressive medical or interventional therapy. The little data that are available on the prognostic value of cTnI during heart transplant are conflicting. After transplantation, the mortality and the morbidity rates remain high compared to those after conventional cardiac surgery. Patients require prolonged monitoring, more intensive medical/mechanical support postoperatively, and repeated hospitalizations, as well as integrated, multidisciplinary approaches. Identifying a sensitive and specific marker of myocyte damage like cTnI may facilitate the selection of the donors and could be useful in the diagnosis and treatment of graft failure and cardiac rejection. The aim of the present study was to examine the pattern of myocardial distress during heart transplantation using serial assays of plasma cTnI as correlates of posttransplant outcome.
Biagioli, B., Simeone, F., Marchetti, L., Giomarelli, P., Maccherini, M., Scolletta, S. (2003). Graft functional recovery and outcome after heart transplant: is troponin I a reliable marker?. TRANSPLANTATION PROCEEDINGS, 35(4), 1519-1522 [10.1016/S0041-1345(03)00365-8].
Graft functional recovery and outcome after heart transplant: is troponin I a reliable marker?
Biagioli Bonizella;Scolletta S.
2003-01-01
Abstract
Plasma concentrations of troponin I (cTnI) provide useful descriptors of myocardial damage as an indicator of clinical outcome. Consequently, cTnI proffers a noninvasive index of potential donor organ dysfunction, reflecting the effectiveness of myocardial protection during the ischemic period and the degree of myocardial insult in the posttransplant recovery period. Assay of cTnI is typically performed for patients with unstable angina and acute coronary syndromes as a prognostic index7 to determine the need for aggressive medical or interventional therapy. The little data that are available on the prognostic value of cTnI during heart transplant are conflicting. After transplantation, the mortality and the morbidity rates remain high compared to those after conventional cardiac surgery. Patients require prolonged monitoring, more intensive medical/mechanical support postoperatively, and repeated hospitalizations, as well as integrated, multidisciplinary approaches. Identifying a sensitive and specific marker of myocyte damage like cTnI may facilitate the selection of the donors and could be useful in the diagnosis and treatment of graft failure and cardiac rejection. The aim of the present study was to examine the pattern of myocardial distress during heart transplantation using serial assays of plasma cTnI as correlates of posttransplant outcome.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/3853
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