We previously described a significant sequence homology between HIV-1 gp120 and the functional sites responsible for the specific binding of snake curare-mimetic neurotoxins and rabies virus glycoprotein to the nicotinic acetylcholine receptor. Here we report findings about the existence of a mechanism of functional molecular mimicry which could enable the binding of HIV-1 gp120 to nicotinic acetylcholine receptors in muscle cells and neurons.
Bracci, L., Lozzi, L., Rustici, M., Neri, P. (1992). Binding of HIV-1 gp120 to the nicotinic receptor. FEBS LETTERS, 311(2), 115-118 [10.1016/0014-5793(92)81380-5].
Binding of HIV-1 gp120 to the nicotinic receptor
Bracci, Luisa;Lozzi, Luisa;
1992-01-01
Abstract
We previously described a significant sequence homology between HIV-1 gp120 and the functional sites responsible for the specific binding of snake curare-mimetic neurotoxins and rabies virus glycoprotein to the nicotinic acetylcholine receptor. Here we report findings about the existence of a mechanism of functional molecular mimicry which could enable the binding of HIV-1 gp120 to nicotinic acetylcholine receptors in muscle cells and neurons.
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https://hdl.handle.net/11365/3845
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