Abstract BACKGROUND: Sarcoidosis is a multisystemic granulomatous disease with an unpredictable clinical course characterized by accumulation of activated proliferating T lymphocytes and mononuclear phagocytes in affected organs. AIMS AND METHODS: The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients followed at the Sarcoidosis Regional Centre in Siena and to analyse chitotriosidase and sIL-2R concentrations in serum of these patients in order to understand their potential as disease markers. RESULTS: Chitotriosidase and sIL-2R concentrations in serum of sarcoidosis patients were found to be significantly higher than in healthy controls (p<0.01) and a positive correlation between the two markers was documented for the first time. Moreover, chitotriosidase and sIL-2R were expressed differently in different radiographic stages of the disease. CONCLUSION: Chitotriosidase and sIL-2R are two markers of sarcoidosis of different origin, the values of which show a correlation in these patients; they are easily detectable in serum and could be useful clinical markers of progression. PMID:[PubMed 18609101 - indexed for MEDLINE]

Bargagli, E., Bianchi, N., Margollicci, M., Olivieri, C., Luddi, A., Coviello, ., et al. (2008). Chitotriosidase and soluble IL-2 receptor: comparison of two markers of sarcoidosis severity. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 68(6), 479-483 [10.1080/00365510701854975].

Chitotriosidase and soluble IL-2 receptor: comparison of two markers of sarcoidosis severity

BARGAGLI, ELENA;BIANCHI, NICOLA;LUDDI A;GROSSO, SALVATORE;ROTTOLI, PAOLA
2008-01-01

Abstract

Abstract BACKGROUND: Sarcoidosis is a multisystemic granulomatous disease with an unpredictable clinical course characterized by accumulation of activated proliferating T lymphocytes and mononuclear phagocytes in affected organs. AIMS AND METHODS: The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients followed at the Sarcoidosis Regional Centre in Siena and to analyse chitotriosidase and sIL-2R concentrations in serum of these patients in order to understand their potential as disease markers. RESULTS: Chitotriosidase and sIL-2R concentrations in serum of sarcoidosis patients were found to be significantly higher than in healthy controls (p<0.01) and a positive correlation between the two markers was documented for the first time. Moreover, chitotriosidase and sIL-2R were expressed differently in different radiographic stages of the disease. CONCLUSION: Chitotriosidase and sIL-2R are two markers of sarcoidosis of different origin, the values of which show a correlation in these patients; they are easily detectable in serum and could be useful clinical markers of progression. PMID:[PubMed 18609101 - indexed for MEDLINE]
Bargagli, E., Bianchi, N., Margollicci, M., Olivieri, C., Luddi, A., Coviello, ., et al. (2008). Chitotriosidase and soluble IL-2 receptor: comparison of two markers of sarcoidosis severity. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 68(6), 479-483 [10.1080/00365510701854975].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/38311
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