Recurrent cytogenetic abnormalities are typically found in about one third of B-cell chronic lymphocytic leukemia patients (B-CLL) by standard cytogenetic analysis and their prognostic relevance is well known. We report a case of a B-CLL patient showing both trisomy 12 and a t(14;22)(q32;q11). Trisomy 12 is often associated with aggressive disease and resistance to chemotherapy, however, our patient is in good health and currently untreated after 7 years, suggesting in this case a relatively good prognosis and a questionable role for translocations involving the 14q32 locus.
|Titolo:||Trisomy 12 and t(14;22)(q32;q11) in a patient with B-cell chronic lymphocytic leukemia|
GOZZETTI, ALESSANDRO (Corresponding)
|Citazione:||Gozzetti, A., Marotta, G., Lenoci, M., Crupi, R., Tozzuoli, D., Calabrese, S., et al. (2004). Trisomy 12 and t(14;22)(q32;q11) in a patient with B-cell chronic lymphocytic leukemia. HEMATOLOGY, 9(5-6), 405-407.|
|Appare nelle tipologie:||1.1 Articolo in rivista|