p60 is a cellular protein that binds to the adenovirus E1A protein complex in virally infected or transformed human cells. In both infected and uninfected cells, p60 was found in a complex with the cdc2 protein kinase. Immune complexes containing p60 and cdc2 display a cell cycle-dependent histone H1 kinase activity that is most active in interphase. The previously described cdc2-p62/cyclin complex also acts as a histone H1 kinase but is maximally active in mitotic metaphase. The shift in the timing of activation of different cdc2-containing complexes suggests that each might play a distinct role in regulation of the cell cycle. © 1989.
Giordano, A., Whyte, P., Harlow, E., Franza, B.R.J., Beach, D., Draetta, G. (1989). A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. CELL, 58(5), 981-990 [10.1016/0092-8674(89)90949-5].
A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells
Giordano, A.;
1989-01-01
Abstract
p60 is a cellular protein that binds to the adenovirus E1A protein complex in virally infected or transformed human cells. In both infected and uninfected cells, p60 was found in a complex with the cdc2 protein kinase. Immune complexes containing p60 and cdc2 display a cell cycle-dependent histone H1 kinase activity that is most active in interphase. The previously described cdc2-p62/cyclin complex also acts as a histone H1 kinase but is maximally active in mitotic metaphase. The shift in the timing of activation of different cdc2-containing complexes suggests that each might play a distinct role in regulation of the cell cycle. © 1989.
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https://hdl.handle.net/11365/37400
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