Before beginning PUVA-therapy it is important to accurately gauge an individual's degree of psoralen photosensitivity. This determination is usually based on an individual's skin phototype or minimal phototoxic dose. Since minimal phototoxic dose is technically complex and time consuming to measure, sun reactivity skin phototype is often used instead; however, it has recently been shown that skin phototype lacks specificity as a predictor of an individual's minimal phototoxic dose. In this study, an artificial neural network was developed to attempt to predict the minimal phototoxic dose from skin colour measurements combined with skin phototype. Our results showed that minimal phototoxic dose was predicted with an error less than 1 J/cm2 in only about half the subjects. In conclusion, minimal phototoxic dose probably cannot be predicted with sufficient accuracy on the basis of skin colour and skin phototype alone.

Rubegni, P., Cevenini, G., Flori, M.l., Barbini, P., & Andreassi, L. (1998). Relationship between minimal phototoxic dose and skin colour plus sun exposure history: a neural network approach. PHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE, 14, 26-30.

Relationship between minimal phototoxic dose and skin colour plus sun exposure history: a neural network approach

RUBEGNI, PIETRO;CEVENINI, GABRIELE;BARBINI, PAOLO;ANDREASSI, LUCIO
1998

Abstract

Before beginning PUVA-therapy it is important to accurately gauge an individual's degree of psoralen photosensitivity. This determination is usually based on an individual's skin phototype or minimal phototoxic dose. Since minimal phototoxic dose is technically complex and time consuming to measure, sun reactivity skin phototype is often used instead; however, it has recently been shown that skin phototype lacks specificity as a predictor of an individual's minimal phototoxic dose. In this study, an artificial neural network was developed to attempt to predict the minimal phototoxic dose from skin colour measurements combined with skin phototype. Our results showed that minimal phototoxic dose was predicted with an error less than 1 J/cm2 in only about half the subjects. In conclusion, minimal phototoxic dose probably cannot be predicted with sufficient accuracy on the basis of skin colour and skin phototype alone.
Rubegni, P., Cevenini, G., Flori, M.l., Barbini, P., & Andreassi, L. (1998). Relationship between minimal phototoxic dose and skin colour plus sun exposure history: a neural network approach. PHOTODERMATOLOGY, PHOTOIMMUNOLOGY & PHOTOMEDICINE, 14, 26-30.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/36677
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo