In rat a single i.p. administration of various benzodiazepines (bromazepam, chlordiazepoxide, clonazepam, diazepam, flunitrazepam, flurazepam, medazepam, nitrazepam) at doses equivalent to those employed in humans brings about a clear-cut decrease of ACTH levels in plasma, without changes in plasma cortisol levels. The repeated administration (0.5 mg/kg every 24 hours for 4 days) of diazepam, in addition to a decrease of plasma ACTH levels, brings about a decrease in plasma cortisol levels. © 1980 The Italian Pharmacological Society.
Bruni, G., Dal Pra, P., Dotti, M.T., Segre, G. (1980). Plasma acth and cortisol levels in benzodiazepine treated rats. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 12(2), 163-175 [10.1016/S0031-6989(80)80074-9].
Plasma acth and cortisol levels in benzodiazepine treated rats
Bruni G.;Dotti M. T.;
1980-01-01
Abstract
In rat a single i.p. administration of various benzodiazepines (bromazepam, chlordiazepoxide, clonazepam, diazepam, flunitrazepam, flurazepam, medazepam, nitrazepam) at doses equivalent to those employed in humans brings about a clear-cut decrease of ACTH levels in plasma, without changes in plasma cortisol levels. The repeated administration (0.5 mg/kg every 24 hours for 4 days) of diazepam, in addition to a decrease of plasma ACTH levels, brings about a decrease in plasma cortisol levels. © 1980 The Italian Pharmacological Society.
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https://hdl.handle.net/11365/35220
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