AIM: To analyze the prevalence of the two commonest thrombophilic mutations, factor V Leiden and prothrombin G20210A, in patients with gastric cancer. METHODS: One hundred and twenty-one patients with primary gastric carcinoma and 130 healthy subjects, comparable for age and sex, were investigated. Factor V Leiden was detected by using polymerase chain reaction and restriction enzyme digestion, and prothrombin G20210A gene mutation by allele-specific PCR. RESULTS: Among the 121 cancer patients, factor V Leiden was found in 4 cases (GA genotype: 3.3%) and prothrombin G20210A in 10 cases (GA genotype: 8.3%). Of the 130 control subjects, factor V Leiden was detected in 6 cases (GA genotype: 4.6%) and prothrombin G20210A in 8 cases (GA genotype: 6.1%). No double heterozygous carriers of both mutations were found in either group. The prevalence of both factor V Leiden and prothrombin G20210A variant was not statistically different between the cancer patients and the healthy subjects. CONCLUSION: Our study suggests that, in gastric cancer, the risk factors of thrombophilic cancer state are on acquired rather than on a genetic basis and that prothrombin G20210A does not seem to be a cofactor in gastric cancer pathogenesis.
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|Titolo:||Prevalence of factor V Leiden and prothrombin G20210A in patients with gastric cancer.|
|Rivista:||WORLD JOURNAL OF GASTROENTEROLOGY|
|Citazione:||Battistelli, S., Stefanoni, M., Genovese, A., Vittoria, A., Cappelli, R., & Roviello, F. (2006). Prevalence of factor V Leiden and prothrombin G20210A in patients with gastric cancer. WORLD JOURNAL OF GASTROENTEROLOGY, 12(26), 4179-4180.|
|Appare nelle tipologie:||1.1 Articolo in rivista|