The emergence and spread of multidrug-resistant (MDR) Mycobacterium tuberculosis (MT) represents a worldwide health care problem because of the difficulty in treating these infections. Development of drug resistance in MT arises mainly by mutation of chromosomal genes. To investigate the evolution of a MT population during a long-lasting infection, the phenotypic and genotypic changes in the drug resistance of 10 sequential MT isolates from a noncompliant chronically infected patient were investigated. During more than 12 years of active disease, a MDR population developed; molecular typing showed one single parental strain that infected the patient and persisted throughout the disease. Molecular analysis of the drug resistance-related genes revealed that discrete subpopulations evolved over time from the parental strain by acquiring and accumulating resistance-conferring mutations to isoniazid, rifampin, and streptomycin. Overall, these observations indicate that during a chronic infection, several subpopulations may coexist in the same patient with different drug susceptibility profiles.
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|Titolo:||Drug resistance evolution of a Mycobacterium tuberculosis strain from a noncompliant patient|
|Rivista:||JOURNAL OF CLINICAL MICROBIOLOGY|
|Citazione:||Meacci, F., Orru', G., Iona, E., Giannoni, F., Piersimoni, C., Pozzi, G., et al. (2005). Drug resistance evolution of a Mycobacterium tuberculosis strain from a noncompliant patient. JOURNAL OF CLINICAL MICROBIOLOGY, 43(7), 3114-3120.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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