Proton-proton distance measurement1 by (IH:IH) difference spectroscopy* and proton r e l a x a t i ~ na~r.e~ n ow well-established approaches for the study of conformation and dynamics of natural products5 and biopolymers.6 An alternative complementary approach was recently demonstrated on model compounds using ('H:l3C) NOE difference ~pectroscopy.~T his latter approach can (i) simultaneously delineate the carbon microenvironment and hence hydrogen bond pairs, (ii) yield proton-carbon distances, and (iii) provide criteria for distinguishing conformations of natural products and biopolymers.

Niccolai, N., Rossi, C., Brizzi, V., & Gibbons, A.W. (1984). Proton-carbon NOE difference spectroscopy studies of carbon microenvironments. internuclear distances and hydrogen bonding in rifamycin S. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 106, 5732-5733 [10.1021/ja00331a056].

Proton-carbon NOE difference spectroscopy studies of carbon microenvironments. internuclear distances and hydrogen bonding in rifamycin S

NICCOLAI, NERI;ROSSI, CLAUDIO;
1984

Abstract

Proton-proton distance measurement1 by (IH:IH) difference spectroscopy* and proton r e l a x a t i ~ na~r.e~ n ow well-established approaches for the study of conformation and dynamics of natural products5 and biopolymers.6 An alternative complementary approach was recently demonstrated on model compounds using ('H:l3C) NOE difference ~pectroscopy.~T his latter approach can (i) simultaneously delineate the carbon microenvironment and hence hydrogen bond pairs, (ii) yield proton-carbon distances, and (iii) provide criteria for distinguishing conformations of natural products and biopolymers.
Niccolai, N., Rossi, C., Brizzi, V., & Gibbons, A.W. (1984). Proton-carbon NOE difference spectroscopy studies of carbon microenvironments. internuclear distances and hydrogen bonding in rifamycin S. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 106, 5732-5733 [10.1021/ja00331a056].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/34618
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