The paramagnetic contributions to the spin-lattice relaxation rates of khellin protons, induced by the presence in an aqueous solution of TEMPO nitroxide, have been analyzed in the interaction of the furochromone with DNA. The relaxation data obtained at different temperatures, nitroxide and DNA concentrations indicate that the average solvent exposure of the furanic moiety of khellin is lower than that of the pyranic group. This feature suggests that the former is the main site of approach of khellin to DNA. © 1990.

Niccolai, N., Lampariello, R., Bovalini, L., Rustici, M., Mascagni, P., Martelli, P. (1990). Solvent Spin-labeling For Investigating the Interaction of Biological Ligands With Macromolecules - A H-1 Paramagnetic Relaxation Study. BIOPHYSICAL CHEMISTRY, 38(1-2), 155-158 [10.1016/0301-4622(90)80050-H].

Solvent Spin-labeling For Investigating the Interaction of Biological Ligands With Macromolecules - A H-1 Paramagnetic Relaxation Study

Niccolai, Neri;Martelli, Paola
1990-01-01

Abstract

The paramagnetic contributions to the spin-lattice relaxation rates of khellin protons, induced by the presence in an aqueous solution of TEMPO nitroxide, have been analyzed in the interaction of the furochromone with DNA. The relaxation data obtained at different temperatures, nitroxide and DNA concentrations indicate that the average solvent exposure of the furanic moiety of khellin is lower than that of the pyranic group. This feature suggests that the former is the main site of approach of khellin to DNA. © 1990.
1990
Niccolai, N., Lampariello, R., Bovalini, L., Rustici, M., Mascagni, P., Martelli, P. (1990). Solvent Spin-labeling For Investigating the Interaction of Biological Ligands With Macromolecules - A H-1 Paramagnetic Relaxation Study. BIOPHYSICAL CHEMISTRY, 38(1-2), 155-158 [10.1016/0301-4622(90)80050-H].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/34103
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo