The furanochromones khellin and visnagin have been characterised by 1H and 13C mono- and bidimensional NMR spectroscopies. Their strong affinity with DNA was experimentally confirmed by the complete disappearance of the furano-chromones' NMR signals upon additions of DNA. An intermolecular interaction between furanochromones and the thymidyl moieties of DNA, stabilized by the formation of a hydrogen bond between the thymidyl NH hydrogen and the C O group of khellin or visnagin, is here proposed. This is suggested by the strong donor-acceptor behavior of these two molecular moieties, as pointed out by a selective 1H-13C Overhauser effect study of the khellin-thymidine model system.
Niccolai, N., Bovalini, L., Martelli, P. (1986). The Mechanisms of Interaction Between Furanochromones and Dna - A Heteronuclear Overhauser Effect Study On the Khellin-thymidine Model System. BIOPHYSICAL CHEMISTRY, 24(3), 217-220 [10.1016/0301-4622(86)85027-X].
The Mechanisms of Interaction Between Furanochromones and Dna - A Heteronuclear Overhauser Effect Study On the Khellin-thymidine Model System
Niccolai, Neri;Bovalini, Lucia;Martelli, Paola
1986-01-01
Abstract
The furanochromones khellin and visnagin have been characterised by 1H and 13C mono- and bidimensional NMR spectroscopies. Their strong affinity with DNA was experimentally confirmed by the complete disappearance of the furano-chromones' NMR signals upon additions of DNA. An intermolecular interaction between furanochromones and the thymidyl moieties of DNA, stabilized by the formation of a hydrogen bond between the thymidyl NH hydrogen and the C O group of khellin or visnagin, is here proposed. This is suggested by the strong donor-acceptor behavior of these two molecular moieties, as pointed out by a selective 1H-13C Overhauser effect study of the khellin-thymidine model system.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/34065
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