Using a specific enzyme-linked immunosorbent assay (ELISA) for human nerve growth factor (NGF), serum levels in patients with systemic lupus erythematosus (SLE) were measured. We found a consistent increase in NGF levels in SLE patients compared with controls. A good correlation exists between serum NGF level and severity of clinical manifestation. We hypothesize that NGF might play a role in the pathogenesis of autoimmune disorders such as SLE.
Bracci-Laudiero, L., Aloe, L., Levi-Montalcini, R., Galeazzi, M., Schilter, D., Scully, J.L., et al. (1993). Increased levels of NGF in sera of systemic lupus erythematosus patients. NEUROREPORT, 4(5), 563-565 [10.1097/00001756-199305000-00025].
Increased levels of NGF in sera of systemic lupus erythematosus patients
Galeazzi, M.;
1993-01-01
Abstract
Using a specific enzyme-linked immunosorbent assay (ELISA) for human nerve growth factor (NGF), serum levels in patients with systemic lupus erythematosus (SLE) were measured. We found a consistent increase in NGF levels in SLE patients compared with controls. A good correlation exists between serum NGF level and severity of clinical manifestation. We hypothesize that NGF might play a role in the pathogenesis of autoimmune disorders such as SLE.
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https://hdl.handle.net/11365/33776
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