Adult rheumatoid arthritis (RA) is a very heterogeneous disease that is associated with HLA-antigens, although no absolute association has been found with any particular HLA type. Forty-one seropositive RA patients have been studied with a local monoclonal antibody named X1 21.4 (9w940), strongly associated with HLA-DRI, DR4, Drw10 antigens, to verify a possible correlation with the disease. The results obtained have also been compared with the data reported on MC1, a serologically defined determinant correlated with RA. X1 21.4 monoclonal antibody appears to be associated with the disease and it could identify one epitope involved in the susceptibility to RA.
Cappellacci, S., Tuzi, T., Mazzilli, M.C., Morellini, M., Lulli, P., Galeazzi, M. (1987). HLA antigens and adult rheumatoid arthritis: a study with a monoclonal antibody. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 5(1), 63-66.
HLA antigens and adult rheumatoid arthritis: a study with a monoclonal antibody
Galeazzi, M.
1987-01-01
Abstract
Adult rheumatoid arthritis (RA) is a very heterogeneous disease that is associated with HLA-antigens, although no absolute association has been found with any particular HLA type. Forty-one seropositive RA patients have been studied with a local monoclonal antibody named X1 21.4 (9w940), strongly associated with HLA-DRI, DR4, Drw10 antigens, to verify a possible correlation with the disease. The results obtained have also been compared with the data reported on MC1, a serologically defined determinant correlated with RA. X1 21.4 monoclonal antibody appears to be associated with the disease and it could identify one epitope involved in the susceptibility to RA.
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https://hdl.handle.net/11365/33771
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