Nitric oxide (NO) is known as a multifaceted bioregulatory agent and an environmental pollutant. We investigated the role of nitric oxide in phospholipid solutions by NMR techniques. A mixture of lipids dissolved in a ternary solvent was used. 31P NMR spectra of this mixture before and after exposure to nitric oxide were recorded. Nitric oxide is a strongly paramagnetic molecule which is able to increase the spin-lattice relaxation rates, and, after its addition, we observed a strong signal broadening at certain solvent concentrations. Many pure phospholipids, dispersed in organic solvents, can form reversed micelles by spontaneous self-association. These results suggest that the lipids form a colloidal dispersion in a homogeneous organic ternary mixture, where the NO solubility increases strongly and produces a broadening of the 31P NMR signal.

Marchettini, N., Rustici, M., Branca, M., Culeddu, N., Fruianu, M., Serra, M.V., et al. (1998). Solubility of nitric oxide (NO) in lipid aggregates as monitored by nuclear magnetic resonance. COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 131(1-3), 1-6 [10.1016/S0927-7757(96)03937-4].

Solubility of nitric oxide (NO) in lipid aggregates as monitored by nuclear magnetic resonance

Marchettini, N.;Tiezzi, E.
1998-01-01

Abstract

Nitric oxide (NO) is known as a multifaceted bioregulatory agent and an environmental pollutant. We investigated the role of nitric oxide in phospholipid solutions by NMR techniques. A mixture of lipids dissolved in a ternary solvent was used. 31P NMR spectra of this mixture before and after exposure to nitric oxide were recorded. Nitric oxide is a strongly paramagnetic molecule which is able to increase the spin-lattice relaxation rates, and, after its addition, we observed a strong signal broadening at certain solvent concentrations. Many pure phospholipids, dispersed in organic solvents, can form reversed micelles by spontaneous self-association. These results suggest that the lipids form a colloidal dispersion in a homogeneous organic ternary mixture, where the NO solubility increases strongly and produces a broadening of the 31P NMR signal.
1998
Marchettini, N., Rustici, M., Branca, M., Culeddu, N., Fruianu, M., Serra, M.V., et al. (1998). Solubility of nitric oxide (NO) in lipid aggregates as monitored by nuclear magnetic resonance. COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 131(1-3), 1-6 [10.1016/S0927-7757(96)03937-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/33426
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